Synthesis, characterization and evaluation of amide based prodrugs of Norfloxacin
نویسندگان
چکیده
A series of new prodrugs (3a-e) of norfloxacin (1) was synthesized using 4-oxo-4-substituted-phenylbutanoic acids (2a-e) as promoiety. An amide-linkage was established between the secondary amino group of 1with the free carboxylic group of 2 following a single-step synthesis. The structure of the synthesized prodrugs was established on the basis of IR, HNMR and mass spectral data. The title compounds (3a-e) were evaluated for in-vitro antibacterial activity against some selected pathogenic bacterial strains. The minimum inhibitory concentration (MIC) results indicated that two compounds (3c & 3d) were excellent in their antibacterial action.
منابع مشابه
Synthesis and characterization of N-Mannich based prodrugs of ciprofloxacin and norfloxacin: In vitro anthelmintic and cytotoxic evaluation
Prodrugs, the inert derivatives of existing drugs have successfully contributed to the modification of their physicochemical properties. The improved antimicrobial potential due to enhanced lipophilicity of some of the synthesized prodrugs of antibacterial agents by various schemes has already been reported. In the current study, synthesis, characterization, and biological evaluation of some mo...
متن کاملSynthesis and Characterization of New Copoly(amide-imide)s Based on 1,3- bis[4,4'-(trimellitimido)phenoxy]propane and Fumaric acid
In this article six new copoly(amide-imide)s (11a-c) were synthesized through the directpolycondensation reaction of 1,3-bis[4,4'-(trimellitimido) phenoxy] propane (6) with 3,3'-diamino diphenyl sulfone (7), 4,4'-diaminodiphenyl ether (8) and 1,5-naphtalene (9) in thepresence of fumaric acid (10) as a second diacid in a medium consisting of N-methyl-2-pyrrolidone, triphenyl phosphite, calcium c...
متن کاملStudy on Synthesis and Characterization of Unsaturated Poly (ester-amide) as Bone Fixation Materials
A new type of unsaturated poly ester-amide was prepared by melt polycondensation and characterized completely. Influence of heat treatment conditions and cross-linking content on mechanical and degradation properties of unsaturated polyester-amide were studied. Results suggested that the newly synthesized unsaturated poly(ester-amide) possessed good heat stabilization properties. Mechanical...
متن کاملSynthesis and characterization of new heat-resistance polymers based on N- (4-carboxy phenyl) trimellitimide and aromatic diamines
Five new aromatic poly(amide-imide)s (5a-e) were synthesized by direct polycondensationreaction of N-(4-carboxy phenyl) trimellitimide (3) with five aromatic diamines (4a-e) by usingtriphenyl phosphite in N-methyl-2-pyrrolidone (NMP) and pyridine at solution containingdissolved CaCl2. All of the polymers were obtained in quantitative yields with inherentviscosities between 0.29-0.40 dL/g. The r...
متن کاملThermally Stable Poly(amide-imide)/Nanocomposites Reinforced Silicate Nanoparticles Containing Bicyclo Segment and Dibenzalacetone Moiety: Synthesis and Characterization
Two new samples of poly(amide-imide)/nanocomposites containing bicyclo segment and dibenzalaceton moiety in the main chain were synthesized by a solution intercalation technique. Poly(amide-imide) (PAI) 8 as a source of polymer matrix was synthesized by the direct polycondensation reaction of N,N´-bis(4-carboxyphenyl)bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic diimide 3 with 2,6-bis(4-amino...
متن کامل